New anti-baldness treatment? Researchers create skin with hair from stem cells

New anti-baldness treatment? Researchers create skin with hair from stem cells

Researchers have grown skin tissues with stem cells from stem cells
Japanese researchers have managed to grow a piece of skin with sebaceous glands from mouse stem cells. The new findings could be an important step in the manufacture of human skin. People with burns could possibly be better treated in the future.

Transplant medicine has made great strides
Transplantation medicine has made great strides in recent years. For example, British scientists have managed to grow artificial noses and ears from stem cells. Last year, US researchers reported an artificial rat's paw that they created using tissue engineering. Even teeth from human urine have already been bred. And now Japanese researchers have succeeded in creating a piece of skin with hair and sebaceous glands from the stem cells of mice. This invention could make it possible to grow skin for humans in the future.

Skin with all natural functions
As the scientists report in the science advances magazine, unlike other biological skin replicas, this skin can take over all natural functions after a transplant to a mouse. The researchers led by Ryoji Takagi from the Tokyo University of Science influenced induced pluripotent stem cells (iPS cells) of mice in such a way that three-dimensional small tissue lumps developed in the laboratory, reports the dpa news agency. The team of scientists influenced the development of the so-called "embryoid bodies", whereupon skin cell layers, hair follicles and other skin structures formed.

Hair grew two weeks after the transplant
According to the researchers, the follicles, like normal hair, contained sebaceous glands and muscle fibers. This tissue was then transplanted into the skin of other mice. A fortnight later, the transplanted nude mice grew hair in this area. In addition, the tissue made normal connections with the surrounding nerve and muscle fibers. It is said that there was no particular risk in stem cell research - tumor formation. Even after three months, the skin tissue was not affected. The scientist Takashi Tsuji, who was involved in the development, said in a communication from the Riken Center for Developmental Biology (CDB) in Japan: “With this new technology, we have successfully simulated the normal functions of the skin. We are getting closer to the dream of creating functioning organs for transplants in the laboratory. ”

First step in the manufacture of human skin
According to the researchers, the next step would be to manufacture human skin using the same method. In the future, this could help patients suffering from burns, scars or hair loss. As the news agency dpa reports, the head of the stem cells and cancer department at the German Cancer Research Center and director of the stem cell institute HI-STEM in Heidelberg, Andreas Trumpp, described the new research on mouse cells as fundamentally interesting. However, it could only be a first step in the manufacture of human skin. “The work is an improvement on an old concept. But you still don't get clean and complete skin, but rather small areas with a particularly large number of hair follicles that stem from the stem cells, ”says Trumpp. In addition, the study - contrary to the researchers' statements - has not yet proven that everything actually works correctly with this new skin, such as the skin barrier or sweat and sebum glands. IPS cells can develop into any cell type. Possible replacement tissue for patients that arises from their own cells, but has the advantage that it is not rejected by the body. (ad)

Author and source information

Video: Cure For Baldness? Stem Cells Help Grow Hair on Hairless Mice